Open Protocols

Protocol Name	Investigatory Role	Biomarkers	Data Collections
Biomarkers of Risk for Colorectal Neoplasia (Team Project #2)	Coordinating	0	0
ctDNA for Monitoring of Stage III Colorectal Cancer	Leading	0	0
Non-Invasive Testing for Advanced Adenomas	Coordinating	0	0

Closed Protocols

Protocol Name	Investigatory Role	Biomarkers	Data Collections
Preliminary Validation of Biomarkers for the Detection of Colorectal Adenomas (Team Project #1)	Involved	1	0

Publications

Publication Name	PubMed ID	Journal
A Blood-Based Assay for Detection of Patients with Advanced Adenomas.	40099973	Cancer Res Commun
Assessing aneuploidy with repetitive element sequencing.	32075918	Proc Natl Acad Sci U S A
Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis.	21041628	Proc Natl Acad Sci U S A
Circulating Tumor DNA as a Marker of Recurrence Risk in Stage III Colorectal Cancer: The α-CORRECT Study.	39865324	J Surg Oncol
Colorectal cancer prevention: Immune modulation taking the stage.	29391185	Biochim Biophys Acta Rev Cancer
Comparative Effectiveness and Cost-Effectiveness of Colorectal Cancer Screening With Blood-Based Biomarkers (Liquid Biopsy) vs Fecal Tests or Colonoscopy.	38552670	Gastroenterology
Detection and localization of surgically resectable cancers with a multi-analyte blood test.	29348365	Science
Detection of aneuploidy in patients with cancer through amplification of long interspersed nucleotide elements (LINEs).	29432176	Proc Natl Acad Sci U S A
Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention.	32345712	Science
Machine learning to detect the SINEs of cancer.	38266106	Sci Transl Med
One year recurrence of aberrant crypt foci.	20570885	Cancer Prev Res (Phila)
Projected Impact and Cost-Effectiveness of Novel Molecular Blood-Based or Stool-Based Screening Tests for Colorectal Cancer.	39467291	Ann Intern Med
PUMA-mediated intestinal epithelial apoptosis contributes to ulcerative colitis in humans and mice.	21490394	J Clin Invest
Tumor DNA as a Cancer Biomarker through the Lens of Colorectal Neoplasia.	33033144	Cancer Epidemiol Biomarkers Prev

Interests

Colorectal Cancer Screening, Colon Cancer Biomarkers

Robert E. Schoen, M.D., M.P.H. is a Professor of Medicine and Epidemiology at the University of Pittsburgh and serves as Director of Colorectal and GI Cancer Prevention and Control Research for the University of Pittsburgh Cancer Institute. His research interests are in evaluating screening for colorectal cancer, encouraging use of screening tests, and in developing new biomarkers for early detection of cancer. He is the chair of the colorectal subcommittee for the NCI Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer screening trial, a randomized study of flexible sigmoidoscopy with over 154,000 participants. Dr. Schoen is evaluating intermediate biomarkers of colorectal cancer including endoscopic markers such as aberrant crypt foci, and serum markers based on nuclear matrix proteins.

To update protocols, publications, biomarkers, or science data, please contact the Data Management and Coordinating Center.

Site

University of Pittsburgh Cancer Institute

Degree(s)

M.D., M.P.H

Email

rschoen@pitt.edu

Fax

412-648-9378

Person ID

1050

EDRN Title

EDRN Principal Investigator

Note

To update contact information, please visit the Data Management and Coordinating Center .