Open Protocols

Protocol Name	Investigatory Role	Biomarkers	Data Collections
Breast Reference Set Application: Paulovich (2018)	Leading	1	0
Combining Avatar Mice and Targeted Mass Spectrometry to Identify Plasma Biomarkers of Breast Cancer	Leading	161	0
Identification of biomarkers for ER+ breast cancer	Involved	0	0

Closed Protocols

This person has no closed protocols at the present moment.

Publications

Publication Name	PubMed ID	Journal
Internal Standard Triggered-Parallel Reaction Monitoring Mass Spectrometry Enables Multiplexed Quantification of Candidate Biomarkers in Plasma.	35767427	Anal Chem
Thermotolerance elicits specific genes in cucurbit plants as a response to the combined effect of viral infection and temperature stress.	40581756	J Exp Bot

Interests

Targeted Proteomics

Development of multiplex thematic assay panels (e.g. targeting cell signaling pathways, protein complexes, etc.) to enable high throughput pharmacodynamics studies for biological studies or lead compound characterization

DNA damage response

•Identification of biomarkers of tissue injury, using exposure to ionizing radiation as a model.
•Characterization of inter- and intra-individual variation in the cellular genotoxic stress response (in both normal and tumor cells), and relation of this variation to clinically relevant endpoints (e.g. risk for malignancy, short and long term toxicity from genotoxic agents, response to genotoxic therapies, etc.).
•Elucidation of biological responses to exposure to sublethal doses of genotoxic agents.

To update protocols, publications, biomarkers, or science data, please contact the Data Management and Coordinating Center.

Site

Fred Hutchinson Cancer Center

Degree(s)

M.D., Ph.D.

Email

apaulovi@fredhutch.org

Person ID

3728

Note

To update contact information, please visit the Data Management and Coordinating Center .