Aliases

• APC Inhibitor
• APOH
• Activated Protein C-Binding Protein
• Anticardiolipin Cofactor
• Apo-H
• Apolipoprotein H
• Apolipoprotein H (Beta-2-Glycoprotein I)
• B2G1
• B2GP1
• B2GPI
• BG
• Beta(2)GPI
• Beta-2-Glycoprotein 1
• Beta-2-Glycoprotein I
• Epididymis Secretory Sperm Binding Protein

Description

From NCBI Gene: Apolipoprotein H, also known as beta-2-glycoprotein I, is a component of circulating plasma lipoproteins. It has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, hemostasis, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome (APS). The anti-beta (2) glycoprotein I antibodies from APS patients, mediate inhibition of activated protein C which has anticoagulant properties. Because beta-2-GPI is the main autoantigen in patients with APS, the disruption of this pathway by autoantibodies may be an important mechanism for thrombosis in patients with APS.[provided by RefSeq, Dec 2019]

Attributes

QA State

Under Review

Type

Protein

HGNC Name

APOH