Aliases

• BA49G10.5
• BPI Fold Containing Family A, Member 1
• BPI Fold-Containing Family A Member 1
• BPIFA1
• LUNX
• Ligand-Binding Protein RYA3
• Lung-Specific Protein X
• NASG
• Nasopharyngeal Carcinoma-Related Protein
• PLUNC
• Palate Lung And Nasal Epithelium Clone Protein
• Palate, Lung And Nasal Epithelium Associated
• Palate, Lung And Nasal Epithelium Carcinoma Associated
• Protein Plunc
• SPLUNC1
• SPURT
• Secretory Protein In Upper Respiratory Tracts
• Tracheal Epithelium Enriched Protein
• Tracheal Epithelium-Enriched Protein
• Von Ebner Protein Hl

Description

The BPIFA1 gene was formerly known as PLUNC. This human gene is the homolog of murine Plunc, and shows the same expression pattern as murine Plunc. Both are expressed in the upper airways and nasopharyngeal regions. Human BPIFA1 may be involved in the airway inflammatory response after exposure to irritants and may be associated with tumor progression. BPIFA1 may also play a role in innate immune responses of the upper airways. And it may serve as a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer. Multiple transcript variants resulting from alternative splicing in the 3' UTR have been detected, but only three full length variants have been isolated.

Attributes

QA State

Under Review

Type

Gene

HGNC Name

BPIFA1