CDH1
- Aliases
-
- CAM 120/80
- CD324
- CDH1
- CDHE
- Cadherin-1
- E-Cadherin
- UVO
- cadherin 1, type 1, E-cadherin (epithelial)
- uvomorulin
- Description
- From NCBI Gene: This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq, Jul 2008]
Attributes
- QA State
- Curated
- Type
- Genomic
- HGNC Name
- CDH1
- Certifications
-
- None
- QA State for Breast
- Curated
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
- Certifications
-
- None
- QA State for Lung
- Curated
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
- Certifications
-
- None
- QA State for Prostate
- Under Review
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
- A targeted proteomics-based pipeline for verification of biomarkers in plasma.
- An epigenetic marker panel for detection of lung cancer using cell-free serum DNA.
- Cadherin superfamily of adhesion molecules in primary lung cancer.
- Construction and analysis of the NCI-EDRN breast cancer reference set for circulating markers of disease.
- The state of molecular biomarkers for the early detection of lung cancer.
- Unlocking biomarker discovery: large scale application of aptamer proteomic technology for early detection of lung cancer.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.