Aliases

• CDK5
• CDKN5
• Cell division protein kinase 5
• PSSALRE
• Serine/threonine-protein kinase PSSALRE
• TPKII catalytic subunit
• Tau protein kinase II catalytic subunit
• cell division protein kinase 5
• cyclin-dependent kinase 5
• protein kinase CDK5 splicing
• serine/threonine-protein kinase PSSALRE
• tau protein kinase II catalytic subunit

Description

From NCBI Gene: This gene encodes a proline-directed serine/threonine kinase that is a member of the cyclin-dependent kinase family of proteins. Unlike other members of the family, the protein encoded by this gene does not directly control cell cycle regulation. Instead the protein, which is predominantly expressed at high levels in mammalian postmitotic central nervous system neurons, functions in diverse processes such as synaptic plasticity and neuronal migration through phosphorylation of proteins required for cytoskeletal organization, endocytosis and exocytosis, and apoptosis. In humans, an allelic variant of the gene that results in undetectable levels of the protein has been associated with lethal autosomal recessive lissencephaly-7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]

Attributes

QA State

Under Review

Type

Protein

HGNC Name

CDK5