Aliases

• C-Src Kinase
• C-Src Tyrosine Kinase
• C-Terminal Src Kinase
• CSK
• CSK, Non-Receptor Tyrosine Kinase
• EC 2.7.10
• EC 2.7.10.2
• Protein-Tyrosine Kinase CYL
• Tyrosine-Protein Kinase CSK

Description

From NCBI Gene: The protein encoded by this gene is involved in multiple pathways, including the regulation of Src family kinases. It plays an important role in T-cell activation through its association with the protein encoded by the protein tyrosine phosphatase, non-receptor type 22 (PTPN22) gene. This protein also phosphorylates C-terminal tyrosine residues on multiple substrates, including the protein encoded by the SRC proto-oncogene, non-receptor tyrosine kinase gene. Phosphorylation suppresses the kinase activity of the Src family tyrosine kinases. An intronic polymorphism (rs34933034) in this gene has been found to affect B-cell activation and is associated with systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017]

Attributes

QA State

Under Review

Type

Protein

HGNC Name

CSK