DCP
- Aliases
-
- DCP
- Des-gamma carboxyprothrombin
- PIVKA II
- PIVKA-II
- Prothrombin Induced by Vitamin K Absence II
- Description
- Des-gamma-carboxy prothrombin (DCP) is a non-functional precursor of prothrombin. Prothrombin, produced by the liver, serves a critical role in normal hemostasis. Functional prothrombin contains several gamma-carboxy-glutamic acid (Gla) residues that are produced as the result of post-translational modification of glutamic acid residues mediated by vitamin K dependent gamma-glutamyl carboxylase. The formation of Gla residues can be impaired in patients with vitamin K deficiency or in patients receiving oral anticoagulant therapy. DCP lacks thrombotic activity and has been shown in multiple studies to be present in the serum of patients with HCC. DCP arises from an acquired defect in the post-translational carboxylation of the pro-thrombin precursor in malignant hepatocytes.
Attributes
- QA State
- Curated
- Type
- Protein
- HGNC Name
- Certifications
- QA State for Liver
- Curated
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
- Alpha-fetoprotein, des-gamma carboxyprothrombin, and lectin-bound alpha-fetoprotein in early hepatocellular carcinoma.
- Des-gamma carboxyprothrombin can differentiate hepatocellular carcinoma from nonmalignant chronic liver disease in american patients.
- Des-gamma-carboxy (abnormal) prothrombin as a serum marker of primary hepatocellular carcinoma.
- Risk factors for hepatocellular carcinoma may impair the performance of biomarkers: a comparison of AFP, DCP, and AFP-L3.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.