EGFR
- Aliases
-
- EGFR
- ERBB
- ERBB1
- Epidermal growth factor receptor
- HER1
- PIG61
- Proto-oncogene c-ErbB-1
- Receptor tyrosine-protein kinase erbB-1
- avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
- c-erbB-1
- cell growth inhibiting protein 40
- cell proliferation-inducing protein 61
- epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)
- mENA
- Description
- From NCBI Gene: The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Attributes
- QA State
- Curated
- Type
- Genomic
- HGNC Name
- EGFR
- Certifications
-
- None
- QA State for Breast
- Curated
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
- Certifications
-
- None
- QA State for Lung
- Under Review
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
- Certifications
-
- None
- QA State for Ovary
- Under Review
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
- Certifications
-
- None
- QA State for Prostate
- Under Review
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
- A framework for evaluating biomarkers for early detection: validation of biomarker panels for ovarian cancer.
- Construction and analysis of the NCI-EDRN breast cancer reference set for circulating markers of disease.
- Lung cancer signatures in plasma based on proteome profiling of mouse tumor models.
- Ovarian cancer biomarker performance in prostate, lung, colorectal, and ovarian cancer screening trial specimens.
- The state of molecular biomarkers for the early detection of lung cancer.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.