EIF3E
- Aliases
-
- EIF-3 P48
- EIF3-P48
- EIF3E
- EIF3S6
- Eukaryotic Translation Initiation Factor 3 Subunit 6
- Eukaryotic Translation Initiation Factor 3 Subunit E
- Eukaryotic Translation Initiation Factor 3, Subunit 6 (48kD)
- Eukaryotic Translation Initiation Factor 3, Subunit 6 48kDa
- Eukaryotic Translation Initiation Factor 3, Subunit E
- INT6
- Mammary Tumor-Associated Protein INT6
- Murine Mammary Tumor Integration Site 6 (Oncogene Homolog)
- Viral Integration Site Protein INT-6 Homolog
- eIF3-p46
- eIF3e
- Description
- From UniProtKB/Swiss-Prot: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins.
Attributes
- QA State
- Under Review
- Type
- Protein
- HGNC Name
- EIF3E
- Certifications
-
- None
- QA State for Breast
- Under Review
Non-Public Biomarker
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Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.