Aliases

• 3-keto acyl-CoA synthase ELOVL2
• EC 2.3.1.n8
• ELOVL FA elongase 2
• ELOVL fatty acid elongase 2
• ELOVL2
• SSC2
• Ssc2
• elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2
• elongation of very long chain fatty acids protein 2

Description

From UniProtKB/Swiss-Prot: Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate in the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.

Attributes

QA State

Under Review

Type

Gene

HGNC Name

ELOVL2