Aliases

• COFS3
• DNA excision repair protein ERCC-5
• DNA repair protein complementing XP-G cells
• EC 3.1.-.-
• ERCC5
• ERCM2
• UVDR
• XPG
• XPG-complementing protein
• XPGC
• Xeroderma pigmentosum group G-complementing protein
• excision repair cross-complementing rodent repair deficiency, complementation group 5
• xeroderma pigmentosum, complementation group G

Description

The ERCC5 gene encodes a single-stranded structure-specific DNA endonuclease involved in DNA excision repair following UV-induced damage. ERCC5 makes the 3'incision in DNA nucleotide excision repair (NER) and acts as a cofactor for a DNA glycosylase that removes oxidized pyrimidines from DNA. The ERCC5 protein may also function in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair. Mutations in this gene cause xeroderma pigmentosum complementation group G (XP-G), which is also referred to as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and increased susceptibility for skin cancer development following UV exposure. Read-through transcription exists between this gene and the neighboring upstream BIVM (basic, immunoglobulin-like variable motif containing) gene.

Attributes

QA State

Under Review

Type

Gene

HGNC Name

ERCC5