GP73
- Aliases
-
- C9orf155
- FLJ22634
- FLJ23608
- GOLM1
- GOLPH2
- GP73
- PSEC0257
- bA379P1.3
- chromosome 9 open reading frame 155
- golgi membrane protein 1
- golgi phosphoprotein 2
- Description
- The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. GP73 is a type II Golgi transmembrane protein. It processes proteins synthesized in the rough endoplasmic reticulum and assists in the transport of protein cargo through the Golgi apparatus. The expression of the GP73 gene has been observed to be upregulated in response to viral infection. Alternatively spliced transcript variants encoding the same protein have been described for this gene. Kladeny, RD. et al. 2000, found significant up-regulation of GOLPH2 expression in human hepatocyte cells infected with a recombinant adenovirus. EDRN investigator Block, TM et al. 2005, found that GP73 over-expression in serum correlate with liver cancer in woodchucks and humans. Chinnayian's lab reported that GP73 transcript was over-expressed in prostate cancer patients urine sediment (Laxman B. et al. 2008).
Attributes
- QA State
- Curated
- Type
- Protein
- HGNC Name
- GOLM1
- Certifications
-
- None
- QA State for Liver
- Under Review
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
- Certifications
-
- None
- QA State for Prostate
- Under Review
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
- A first-generation multiplex biomarker analysis of urine for the early detection of prostate cancer.
- GOLPH2 expression may serve as diagnostic marker in seminomas.
- GP73, a resident Golgi glycoprotein, is a novel serum marker for hepatocellular carcinoma.
- N-linked glycosylation of the liver cancer biomarker GP73.
- Novel fucosylated biomarkers for the early detection of hepatocellular carcinoma.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.