Aliases

• AMF
• Autocrine motility factor
• EC 5.3.1.9
• GNPI
• GPI
• NLK
• Neuroleukin
• PGI
• PHI
• Phosphoglucose isomerase
• Phosphohexose isomerase
• SA-36
• SA36
• Sperm antigen 36
• autocrine motility factor
• glucose phosphate isomerase
• glucose-6-phosphate isomerase
• hexose monophosphate isomerase
• hexosephosphate isomerase
• neuroleukin
• oxoisomerase
• phosphoglucose isomerase
• phosphohexomutase
• phosphohexose isomerase
• phosphosaccharomutase
• sperm antigen 36
• sperm antigen-36

Description

From NCBI Gene: This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phophsate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Attributes

QA State

Under Review

Type

Protein

HGNC Name

GPI