Aliases

• EC 1.11.1.9
• Extracellular glutathione peroxidase
• GPX3
• GPXP
• GPx-3
• GPx-P
• GSHPx-3
• GSHPx-P
• Plasma glutathione peroxidase
• extracellular glutathione peroxidase
• glutathione peroxidase 3
• glutathione peroxidase 3 (plasma)
• plasma glutathione peroxidase

Description

The GPX3 gene product, glutathione peroxidase 3, is a member of the glutathione peroxidase family. Family members are involved in the detoxification of hydrogen peroxide. Glutathione peroxidase is one of the most important antioxidant enzymes in humans. The GPX3 protein is one of only a few proteins known in higher vertebrates to contain selenocysteine, which occurs at the active site of glutathione peroxidase and is coded by UGA, that normally functions as a translation termination codon. Selenoprotein mRNAs contain a conserved secondary structure in the 3' UTR that is required for the distinction of UGA stop from UGA selenocysteine. The selenocysteine insertion sequence (SECIS) is around 60 nt in length and adopts a hairpin structure which is sufficiently well-defined and conserved to act as a computational screen for selenoprotein genes.

Attributes

QA State

Under Review

Type

Gene

HGNC Name

GPX3