Aliases

• 28 kDa heat shock protein
• CMT2F
• Estrogen-regulated 24 kDa protein
• HMN2B
• HS.76067
• HSP 27
• HSP27
• HSP28
• HSPB1
• Heat shock 27 kDa protein
• Hs.76067
• Hsp25
• HspB1
• SRP27
• Stress-responsive protein 27
• estrogen-regulated 24 kDa protein
• heat shock 27 kDa protein
• heat shock 27kD protein 1
• heat shock 27kDa protein 1
• heat shock protein beta-1
• stress-responsive protein 27

Description

From NCBI Gene: This gene encodes a member of the small heat shock protein (HSP20) family of proteins. In response to environmental stress, the encoded protein translocates from the cytoplasm to the nucleus and functions as a molecular chaperone that promotes the correct folding of other proteins. This protein plays an important role in the differentiation of a wide variety of cell types. Expression of this gene is correlated with poor clinical outcome in multiple human cancers, and the encoded protein may promote cancer cell proliferation and metastasis, while protecting cancer cells from apoptosis. Mutations in this gene have been identified in human patients with Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. [provided by RefSeq, Aug 2017]

Attributes

QA State

Under Review

Type

Gene

HGNC Name

HSPB1