HYAL2
- Aliases
-
- EC 3.2.1.35
- HYAL2
- Hyal-2
- Hyaluronoglucosaminidase-2
- LUCA2
- LuCa-2
- Lung carcinoma protein 2
- PH-20 homolog
- PH20 homolog
- hyal-2
- hyaluronidase 2
- hyaluronidase-2
- hyaluronoglucosaminidase 2
- hyaluronoglucosaminidase-2
- lung carcinoma protein 2
- lysosomal hyaluronidase
- Description
- HYAL2, or hyaluronoglucosaminidase 2, is a weak acid-active hyaluronidase. HYAL2 breaks down hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The HYAL2 gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. There are two known alternatively spliced transcript variants.
Attributes
- QA State
- Under Review
- Type
- Protein
- HGNC Name
- HYAL2
- Certifications
-
- None
- QA State for Lung
- Under Review
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.