IGFBP1
- Aliases
-
- AFBP
- IBP-1
- IBP1
- IGF-BP25
- IGF-binding protein 1
- IGFBP-1
- IGFBP1
- PP12
- Placental protein 12
- alpha-pregnancy-associated endometrial globulin
- hIGFBP-1
- insulin-like growth factor binding protein 1
- Description
- IGFBP1, a secreted protein, is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. It binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. IGFBP1 promotes cell migration.
Attributes
- QA State
- Curated
- Type
- Protein
- HGNC Name
- IGFBP1
- Certifications
-
- None
- QA State for Breast
- Under Review
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
- Certifications
-
- None
- QA State for Ovary
- Curated
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
- Certifications
-
- None
- QA State for Pancreas
- Under Review
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
- A framework for evaluating biomarkers for early detection: validation of biomarker panels for ovarian cancer.
- Insulin-like growth factor binding proteins IGFBP3, IGFBP4, and IGFBP5 predict endocrine responsiveness in patients with ovarian cancer.
- Ovarian cancer biomarker performance in prostate, lung, colorectal, and ovarian cancer screening trial specimens.
- Entrez Protein Reference Sequence for insulin-like growth factor-binding protein 1 precursor [Homo sapiens]
- HGNC entry for human insulin-like growth factor binding protein 1 IGFBP1
- KEGG entry for human insulin-like growth factor binding protein 1 IGFBP1
- UniProtKB/Swiss-Prot entry for P08833 (IBP1_HUMAN)
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.