ITIH4
- Aliases
-
- Gp120
- H4P
- IHRP
- ITI heavy chain H4
- ITI-HC4
- ITIH4
- ITIHL1
- Inter-alpha-inhibitor heavy chain 4
- Inter-alpha-trypsin inhibitor family heavy chain-related protein
- Inter-alpha-trypsin inhibitor heavy chain H4
- PK-120
- PK120
- PRO1851
- Plasma kallikrein sensitive glycoprotein 120
- Description
- The inter-alpha-trypsin inhibitors (ITI) are a family of plasma protease inhibitors, assembled from a light chain - bikunin, encoded by AMBP - and five homologous heavy chains (encoded by ITIH1, ITIH2, ITIH3, ITIH4, and ITIH5), contributing to extracellular matrix stability by covalent linkage to hyaluronan. ITIH4 is secreted into the blood, where it is cleaved by plasma kallikrein into two smaller forms. Expression of the ITIH4 gene has been detected only in liver, and it seems to be upregulated during surgical trauma. This gene is part of a cluster of similar genes on chromosome 3. Two transcript variants encoding different isoforms have been found for this gene.
Attributes
- QA State
- Curated
- Type
- Protein
- HGNC Name
- ITIH4
- Certifications
-
- None
- QA State for Ovary
- Curated
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
- HGNC entry for human inter-alpha-trypsin inhibitor heavy chain family, member 4 ITIH4
- KEGG entry for human inter-alpha-trypsin inhibitor heavy chain family, member 4 ITIH4
- Protein RefSeq sequence for inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor [Homo sapiens]
- UniProtKB/Swiss-Prot entry for Q14624 (ITIH4_HUMAN)
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.