Aliases

• CD309
• CD309 antigen
• EC 2.7.10.1
• FLK-1
• FLK1
• Fetal liver kinase 1
• KDR
• Kinase insert domain receptor
• Protein-tyrosine kinase receptor flk-1
• VEGFR
• VEGFR-2
• VEGFR2
• fetal liver kinase 1
• fetal liver kinase-1
• kinase insert domain receptor (a type III receptor tyrosine kinase)
• protein-tyrosine kinase receptor Flk-1
• soluble VEGFR2
• tyrosine kinase growth factor receptor
• vascular endothelial growth factor receptor 2

Description

From NCBI Gene: Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009]

Attributes

QA State

Under Review

Type

Protein

HGNC Name

KDR