PSA

Aliases
  • APS
  • EC 3.4.21.77
  • Gamma-seminoprotein
  • KLK2A1
  • KLK3
  • KLK3 (PSA)
  • Kallikrein-3
  • P-30 antigen
  • PSA
  • Semenogelase
  • Seminin
  • gamma-seminoprotein
  • hK3
  • kallikrein 3, (prostate specific antigen)
  • kallikrein-3
  • kallikrein-related peptidase 3
  • prostate specific antigen
  • prostate-specific antigen
  • semenogelase
  • seminin
Description
KLK3, also known as PSA, or prostate specific antigen, a member of the kallikrein subgroup of serine proteases, is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Kallikreins are increasingly thought to be involved in carcinogenesis, and many act as cancer biomarkers. The product of the KLK3 gene is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum. KLK3, or PSA, is well known for its role in diagnosing and monitoring prostate cancer. There are several isoforms of KLK3, generated by alternate splicing and transcript variants.
Attributes
QA State
Curated
Type
Proteomic
HGNC Name
KLK3
Certifications
  • None
QA State for Breast
Curated

 Non-Public Biomarker

Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.

Certifications
  • None
QA State for Prostate
Curated

 Non-Public Biomarker

Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.

 Non-Public Biomarker

Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.

 Non-Public Biomarker

Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.