Aliases

• KIAA0533
• KIAA1907
• LAMA5
• Laminin Alpha-5 Chain
• Laminin subunit alpha-5
• Laminin, Alpha 5
• Laminin-10 subunit alpha
• Laminin-11 subunit alpha
• Laminin-15 subunit alpha

Description

LAMA5 belongs to the alpha subfamily of laminin chains and is a major component of basement membranes. Two transcript variants encoding different isoforms have been found for this gene. The laminins, a family of heterotrimeric extracellular glycoproteins, affect tissue development and integrity in such diverse organs as the kidney, lung, skin, and nervous system. It is thought that laminins mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Alpha-5 is a subunit of laminin-10 (laminin-511), laminin-11 (laminin-521) and laminin-15 (laminin-523). LAMA5 is expressed in heart, lung, kidney, skeletal muscle, pancreas, retina and placenta. There is little or no expression in brain and liver.

Attributes

QA State

Under Review

Type

Protein

HGNC Name

LAMA5