Aliases

• CXXC-type zinc finger protein 3
• CXXC3
• MBD1
• Methyl-CpG-binding protein MBD1
• PCM1
• Protein containing methyl-CpG-binding domain 1
• RFT
• methyl-CpG binding domain protein 1
• methyl-CpG binding domain protein 1 isoform PCM1
• methyl-CpG-binding domain protein 1
• protein containing methyl-CpG-binding domain 1
• the regulator of fibroblast growth factor 2 (FGF-2) transcription

Description

From NCBI Gene: The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains multiple domains: MBD at the N-terminus that functions both in binding to methylated DNA and in protein interactions; several CXXC-type zinc finger domains that mediate binding to non-methylated CpG dinucleotides; transcriptional repression domain (TRD) at the C-terminus that is involved in transcription repression and in protein interactions. Numerous alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Feb 2011]

Attributes

QA State

Under Review

Type

Protein

HGNC Name

MBD1