Aliases

• EDSS1
• Ig superfamily receptor LNIR
• LNIR
• NECTIN4
• Nectin-4
• PRR4
• PVRL4
• nectin 4
• poliovirus receptor-related 4
• poliovirus receptor-related protein 4

Description

The PVRL4 protein, also known as nectin-4, is a member of the nectin family. PVRL4 contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with PVRL2/nectin-1. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder.

Attributes

QA State

Under Review

Type

Protein

HGNC Name

NECTIN4