PAM
- Aliases
-
- PAL
- PAM
- PHM
- Pancreatic Peptidylglycine Alpha-Amidating Monooxygenase
- Peptidyl Alpha-Amidating Enzyme
- Peptidyl-Alpha-Hydroxyglycine Alpha-Amidating Lyase
- Peptidyl-Glycine Alpha-Amidating Monooxygenase
- Peptidylamidoglycolate Lyase
- Peptidylglycine 2-Hydroxylase
- Peptidylglycine Alpha-Amidating Monooxygenase
- Peptidylglycine Alpha-Hydroxylating Monooxygenase
- Description
- From NCBI Gene: This gene encodes a multifunctional protein. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme includes two domains with distinct catalytic activities, a peptidylglycine alpha-hydroxylating monooxygenase (PHM) domain and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) domain. These catalytic domains work sequentially to catalyze the conversion of neuroendocrine peptides to active alpha-amidated products. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Attributes
- QA State
- Under Review
- Type
- Protein
- HGNC Name
- PAM
- Certifications
-
- None
- QA State for Breast
- Under Review
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.