POLR2L
- Aliases
-
- DNA-directed RNA polymerase III subunit L
- DNA-directed RNA polymerases I, II, and III subunit RPABC5
- POLR2L
- RBP10
- RNA polymerase II 7.6 kDa subunit
- RNA polymerases I, II, and III subunit ABC5
- RPABC5
- RPB10
- RPB10 homolog
- RPB10beta
- RPB7.6
- hRPB7.6
- hsRPB10b
- polymerase (RNA) II (DNA directed) polypeptide L (7.6kD)
- polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
- Description
- POLR2L is the central component of RNA polymerase II. RNA polymerase II is the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit may be shared by the other two DNA-directed RNA polymerases, I and III. RNA polymerases, or Pols, are composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is thought to be part of the core element with the central large cleft.
Attributes
- QA State
- Curated
- Type
- Protein
- HGNC Name
- POLR2L
- Certifications
-
- None
- QA State for Breast
- Under Review
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
- Development and validation of sandwich ELISA microarrays with minimal assay interference.
- Discovery and preliminary confirmation of novel early detection biomarkers for triple-negative breast cancer using preclinical plasma samples from the Women's Health Initiative observational study.
- Plasma biomarker profiles differ depending on breast cancer subtype but RANTES is consistently increased.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.