proPSA
- Aliases
-
- [-2]proPSA
- free prostate-specific antigen (PSA) isoform
- proPSA
- Description
- ProPSA (-2), or [-2]proPSA, is a PSA isoform which has a leader peptide (-2) amino acids at its N terminal region and does not interact with ACT or alpha-2-macroglobulin or spermidine and therefore is detected as a separate isoform. ProPSA is produced primarily in the peripheral zone of the prostate gland and therefore is very useful in distinguishing between prostate cancer patients with PSA range of 2-10, from those who have BPH. Percent proPSA is the ratio of proPSA to free PSA. In July 2012 the FDA approved an assay measuring levels of [-2]proPSA for monitoring and diagnostic purposes.
Attributes
- QA State
- Curated
- Type
- Protein
- HGNC Name
- Certifications
- QA State for Prostate
- Curated
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
- A multicenter study of [-2]pro-prostate specific antigen combined with prostate specific antigen and free prostate specific antigen for prostate cancer detection in the 2.0 to 10.0 ng/ml prostate specific antigen range.
- A prospective, multicenter, National Cancer Institute Early Detection Research Network study of [-2]proPSA: improving prostate cancer detection and correlating with cancer aggressiveness.
- From prostate-specific antigen (PSA) to precursor PSA (proPSA) isoforms: a review of the emerging role of proPSAs in the detection and management of early prostate cancer.
- Multi-center analytical performance evaluation of the Access Hybritech® p2PSA immunoassay.
- [-2]proenzyme prostate specific antigen for prostate cancer detection: a national cancer institute early detection research network validation study.
- 510(k) SUBSTANTIAL EQUIVALENCE DETERMINATION DECISION SUMMARY
- Draft Directional Insert
- FDA Medical Device description of Hybritech p2PSA assay
- Genecards record for human kallikrein 3, also known as PSA
- NCBI Gene entry for human KLK3
- NCI Fact Sheet for Prostate-Specific Antigen (PSA) Test
- National Cancer Institute News Note
- Summary of Safety and Effectiveness Data (SSED)
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.