Aliases

• C5
• Epididymis Secretory Protein Li 276
• HEL-S-276
• HSPC
• PSMA7
• Proteasome (Prosome, Macropain) Subunit, Alpha Type, 7
• Proteasome 20S Subunit Alpha 7
• Proteasome Subunit Alpha 4
• Proteasome Subunit Alpha 7
• Proteasome Subunit Alpha Type-7
• Proteasome Subunit RC6-1
• Proteasome Subunit XAPC7
• Proteasome Subunit Α4
• RC6-1
• Testicular Tissue Protein Li 151
• XAPC7

Description

From NCBI Gene: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the peptidase T1A family that functions as a 20S core alpha subunit. The encoded protein interacts with the hepatitis B virus X protein and plays a role in regulating hepatitis C virus internal ribosome entry site (IRES) activity, an activity essential for viral replication. The encoded protein also plays a role in the cellular stress response by regulating hypoxia-inducible factor-1alpha. A pseudogene of this gene is located on the long arm of chromosome 9. [provided by RefSeq, Jul 2012]

Attributes

QA State

Under Review

Type

Protein

HGNC Name

PSMA7