Aliases

• 40S ribosomal protein S27a
• CEP80
• RPS27A
• S27A
• UBA80
• UBC
• UBCEP1
• UBCEP80
• Uba80
• Ubiquitin carboxyl extension protein 80
• ribosomal protein S27a
• ubiquitin C
• ubiquitin and ribosomal protein S27a
• ubiquitin carboxyl extension protein 80
• ubiquitin-40S ribosomal protein S27a
• ubiquitin-CEP80

Description

Ubiquitin, one of the most highly conserved proteins, is coded for by a family of genes whose translation products give rise to several different proteins. There are four genes that code for ubiquitin: UBB, UBC, RPS27A, and UBA52. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. UBA52 and RPS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains. This gene, RPS27A, encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein S27a at the C terminus. When expressed in yeast, the protein is post-translationally processed, generating free ubiquitin monomer and ribosomal protein S27a. Ribosomal protein S27a is a component of the 40S subunit of the ribosome and belongs to the S27AE family of ribosomal proteins. Multiple alternatively spliced transcript variants that encode the same proteins have been identified.

Attributes

QA State

Under Review

Type

Protein

HGNC Name

RPS27A