Aliases

• 34/67 kDa laminin receptor
• 37LRP
• 40S ribosomal protein SA
• 67LR
• 67kD, ribosomal protein SA
• Colon carcinoma laminin-binding protein
• LAMBR
• LAMR1
• LBP
• LBP/p40
• LRP
• LRP/LR
• LamR
• Laminin-binding protein precursor p40
• Multidrug resistance-associated protein MGr1-Ag
• NEM/1CHD4
• RPSA
• RSSA
• laminin receptor 1
• laminin receptor 1 (67kD, ribosomal protein SA)
• p40
• ribosomal protein SA

Description

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. The amino acid sequence of laminin receptor 1 is highly through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Cell-adhesive protein LAMR1 plays an important role in the processes of cancer proliferation, invasion and metastasis. LAMR1 antigens have been found to be targets of autoantibodies in subjects newly diagnosed with lung cancer.

Attributes

QA State

Accepted

Type

Protein

HGNC Name

RPSA