Aliases

• CBG
• SERPINA6
• corticosteroid binding globulin
• serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
• serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
• transcortin

Description

SERPINA6, an alpha-globulin protein with corticosteroid-binding properties, is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. SERPINA is syntesized in the liver. Defects in SERPINA6 are a cause of corticosteroid-binding globulin deficiency (CBG deficiency). CBG deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo/hypertension and muscle fatigue.

Attributes

QA State

Under Review

Type

Protein

HGNC Name

SERPINA6