Aliases

• CD202B
• CD202b antigen
• EC 2.7.10.1
• Endothelial tyrosine kinase
• TEK
• TEK tyrosine kinase, endothelial
• TIE-2
• TIE2
• Tunica interna endothelial cell kinase
• Tyrosine kinase with Ig and EGF homology domains-2
• Tyrosine-protein kinase receptor TEK
• Tyrosine-protein kinase receptor TIE-2
• VMCM
• VMCM1
• angiopoietin-1 receptor
• endothelial tyrosine kinase
• hTIE2
• p140 TEK
• soluble TIE2 variant 1
• soluble TIE2 variant 2
• tunica interna endothelial cell kinase
• tyrosine kinase with Ig and EGF homology domains-2
• tyrosine-protein kinase receptor TEK
• tyrosine-protein kinase receptor TIE-2
• venous malformations, multiple cutaneous and mucosal

Description

From NCBI Gene: This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]

Attributes

QA State

Under Review

Type

Protein

HGNC Name

TEK