Aliases

• EPI
• Extrinsic Pathway Inhibitor
• LACI
• Lipoprotein-Associated Coagulation Inhibitor
• TFI
• TFPI
• TFPI1
• Tissue Factor Pathway Inhibitor
• anti-convertin
• tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

Description

This gene encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. The encoded protein is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been confirmed. [provided by RefSeq, Jul 2008] (From NCBI Entrez Gene, June 2014)

Attributes

QA State

Under Review

Type

Protein

HGNC Name

TFPI