TP63
- Aliases
-
- AIS
- B(p51A)
- B(p51B)
- CUSP
- Chronic ulcerative stomatitis protein
- EEC3
- KET
- Keratinocyte transcription factor KET
- LMS
- NBP
- OFC8
- P63
- P73H
- P73L
- RHS
- SHFM4
- TP53L
- TP63
- TP73L
- Transformation-related protein 63
- Tumor protein p73-like
- amplified in squamous cell carcinoma
- p40
- p51
- p53CP
- p63
- p73H
- p73L
- tumor protein 63
- tumor protein p53-competing protein
- tumor protein p53-like
- tumor protein p63
- tumor protein p63 deltaN isoform delta
- Description
- TP63 is a member of the p53 family of transcription factors. It acts as a sequence specific DNA binding transcriptional activator or repressor. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. TP63 may be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. It is involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis.
Attributes
- QA State
- Under Review
- Type
- Gene
- HGNC Name
- TP63
- Certifications
-
- None
- QA State for Lung
- Under Review
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
- Certifications
-
- None
- QA State for Prostate
- Under Review
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.