Aliases

• F8VWF
• VWD
• VWF
• von Willebrand factor

Description

Important in the maintenance of hemostasis, VWF, a secreted protein found in extracellular space, promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. It also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. Defects in VWF are the cause of von Willebrand disease, a group of hemorrhagic disorders in which the von Willebrand factor is either quantitatively or qualitatively abnormal resulting in altered platelet function.

Attributes

QA State

Under Review

Type

Protein

HGNC Name

VWF