Aliases

• 14-3-3 protein T-cell
• 14-3-3 protein tau
• 14-3-3 protein theta
• 14-3-3 theta
• 1C5
• Protein HS1
• YWHAQ
• protein tau
• tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide

Description

YWHAQ, also known as 14-3-3 theta, belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. The 14-3-3 proteins have a wide range of ligands, are involved in a variety of biological pathways, and are known to be overexpressed in some human lung cancers, suggesting that they may play a role in tumorigenesis. 14-3-3 theta is an adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. It binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. 14-3-3 theta antigens have been found to be targets of autoantibodies in subjects newly diagnosed with lung cancer.

Attributes

QA State

Accepted

Type

Protein

HGNC Name

YWHAQ