Abbreviated Name

COLON CANCER REF

Lead Investigator

— University of Michigan

Coordinating Investigator

Zheng, Yingye — Fred Hutchinson Cancer Center

Involved Investigators

• — University of Michigan
• Srivastava, Sudhir — National Cancer Institute
• Zheng, Yingye — Fred Hutchinson Cancer Center

Abstract

The Early Detection Research Network, Great Lakes-New England Clinical, Epidemiological and Validation Center (GLNE CVC) announces the availability of serum, plasma and urine samples for the early detection for colon cancer and validation studies.

Aims

Two prospective studies were used to collect samples to make this reference set. GLNE 001, (Preliminary Clinical Characterization of Serum, Plasma, and Urine Biomarkers for Colorectal Neoplasms) was a prospective, cross-sectional clinical trial to collect serum, plasma, urine, and common data elements on subjects undergoing routine screening colonoscopy or subjects undergoing surgery or endoscopy for colon cancer. GLNE 007 (Evaluation of Stool Based Markers for the Early Detection of Colorectal Cancers and Adenomas) is an on-going prospective, cross-sectional clinical to collect serum, plasma, urine, stool, and common data elements. In both protocols, subjects were undergoing routine colonoscopy (or being seen in surgery clinic for colorectal cancer) when the samples were collected. Samples were collected while the target lesions were still in place in the colon. Subjects were either normal (without adenomas or cancer), with pathologically confirmed adenomas or pathologically confirmed colorectal adenocarcinoma. Exclusion criteria for both protocols included known hepatitis C or HIV, ulcerative colitis, Crohns’s Disease or IBD, history of cancer within 3 years, or genetic colon diseases including FAP or HNPCC. Samples were collected from 4 sites around North America.

Analytic Method

N/A

Outcome

The Early Detection Research Network, Great Lakes-New England Clinical, Epidemiological and Validation Center (GLNE CVC) announces the availability of serum, plasma and urine samples for the early detection for colon cancer and validation studies.

Publications

• No publications available at this time for this protocol.

Biomarkers

• No biomarkers available at this time for this protocol.

Data Collections

• No data collections available at this time for this protocol.

 Team Project

Start Date

Feb 1 2008

Estimated Finish Date

Feb 1 2009

Finish Date

Jun 4 2009

Protocol ID

251

Protocol Type

Reference Set

Fields of Research

• Other

Collaborative Group

G.I. and Other Associated Cancers Research Group

Cancer Types

• Malignant neoplasm of colon