Liver Rapid Reference Set Application: Timothy Block - Drexel Univ (2008)
- Abbreviated Name
- Liver Rapid Ref Set App: Block (2008)
- Lead Investigator
- Block, Timothy — Drexel University College of Medicine
- Coordinating Investigator
- Zheng, Yingye — Fred Hutchinson Cancer Center
- Involved Investigators
Abstract
No abstract availalbe.
Aims
Directly compare GP73 and fucosylated markers against AFP, AFP-L3 and DCP as well as test them in combination with these markers
Analytic Method
For data analysis, Receiver Operating Curves (ROC) should be generated for the Gp73 and fucosylated kininogen either alone and in combination with AFP, AFP-L3 and DCP and the area under the curve determined (AUROC). No training sets will be required. Markers will be directly compared by their AUROC values and ranked accordingly. The following will be criteria for advancement of a biomarker status and further testing: Statistically significant with alpha = 10% AUROC improvement in the distinction of cirrhosis from HCC with the addition of marker(s) to AFP alone for the full set of samples OR in defined subsets, e.g. AFP negatives, early tumor stage. The ultimate target is to find a combination of markers that will improve on current AFP-alone sensitivity and specificity, such that we will be able to achieve > 90% sensitivity and > 85% specificity for the distinction of cirrhosis from HCC.
Outcome
The goal of this application is to determine if the levels of serum GP73 and fucosylated kininogen/acute phase proteins can be used to detect hepatocellular carcinoma (HCC) in the background of liver cirrhosis. The use of the validation set would allow us to directly compare GP73 and fucosylated markers against AFP, AFP-L3 and DCP as well as test them in combination with these markers
Publications
- No publications available at this time for this protocol.
Biomarkers
Data Collections
- No data collections available at this time for this protocol.
- Start Date
- Apr 15 2008
- Estimated Finish Date
- Mar 17 2009
- Finish Date
- Mar 16 2009
- Protocol ID
- 285
- Protocol Type
- Reference Set
- Fields of Research
-
- Proteomics
- Collaborative Group
- G.I. and Other Associated Cancers Research Group
- Cancer Types
-
- Liver cell carcinoma
- Phased Status
- 1