Lung Reference Set A Application: Dawn Coverley- University of York (2011)

Abbreviated Name
Lung Ref Set A App: Coverley (2011)
Lead Investigator
Coverley, DawnUniversity of York
Coordinating Investigator
Zheng, Yingye Fred Hutchinson Cancer Center
Involved Investigators

Abstract

No abstract availalbe.

Aims

There are four primary clinical questions to be addressed in the pre-validation study: 1) Whether b-variant Ciz1 as a single plasma biomarker has the potential for adding value to current clinical tests (CT scan and/or PET scan) in the diagnostic evaluation of pulmonary nodules with a goal of reducing invasive tests (PET or tissue biopsy) or futile thoracotomies; 2) Whether b-variant Ciz1 as a single plasma biomarker has the potential for adding value to current tests (CT scan and/or PET scan) in the early diagnosis/detection of lung cancer in high risk individuals, with a goal of reducing invasive tests (PET or tissue biopsy) or futile thoracotomies and more importantly, missed cures; and 3) Whether b-variant Ciz1 as a single plasma biomarker has the potential for adding value to current clinical tests (CT scan, PET scan and biopsies) in the staging of lung cancer; and, 4) Whether b-variant Ciz1 as a single plasma biomarker has the potential for adding value to current clinical tests (e.g., CT scan, PET scan and biopsies) in determining prognosis of lung cancer patients; and, A Secondary clinical question is whether b-variant Ciz1 as part of a panel of biomarkers has the potential for adding value to one or more of the above primary clinical utilities.

Analytic Method

Provide adequate detail concerning how statistical analysis of your data generated from the Reference Set(s) samples will be performed and a justification that the requested References Set(s) is/are large enough to demonstrate the utility of the biomarker. Describe the statistical resources at your disposal. If you require statistical support, the EDRN/SPOREs can assist you with this.

Comments

No Data Received at DMCC. Assay didn't work well on the samples provided.

Outcome

A variant of the nuclear matrix factor Ciz1 is prevalent in lung cancer cell lines and tumours, but not in adjacent lung tissue, giving rise to a protein that is stable enough to be detected in just one ul of plasma. This project evaluates the potential of variant Ciz1 as an early detection tool for lung cancer, using variant-selective antibodies.

Publications

  • No publications available at this time for this protocol.

Biomarkers

Data Collections

  • No data collections available at this time for this protocol.
Start Date
Sep 28 2011
Estimated Finish Date
Sep 27 2012
Finish Date
Mar 27 2012
Protocol ID
341
Protocol Type
Reference Set
Fields of Research
  • Proteomics
Collaborative Group
Lung and Upper Aerodigestive Cancers Research Group
Cancer Types
  • Malignant neoplasm of bronchus and lung
Phased Status
1

Associated Forms