PASS Reference Set Application: Lin UW (2010) TMPRSS2-ERG-PCA-PASS

Abbreviated Name
PASS Ref Set App: Lin (2010) TMPRSS2-ERG
Lead Investigator
Lin UW, Daniel W.University of Washington
Coordinating Investigator
No coordinating investigator
Involved Investigators

Abstract

No abstract availalbe.

Aims

1.   Assess the frequency of TMPRSS2:ERG gene-fusion in whole urines of an active surveillance population. 2.   Evaluate urinary TMPRSS2:ERG and PCA3 levels and assess if there is a correlation with progression. 3.   Evaluate longitudinal changes in urinary TMPRSS2:ERG and PCA3 levels and assess if there is a correlation with progression.

Analytic Method

Gen-Probes TMA assay

Outcome

Active surveillance is used to manage low-risk prostate cancer. Both PCA3 and TMPRSS2:ERG are promising biomarkers that may be associated with aggressive disease. This study examines the correlation of these biomarkers with higher cancer volume and grade determined at the time of biopsy in an active surveillance cohort.

Publications

Biomarkers

Data Collections

  • No data collections available at this time for this protocol.
Start Date
Jun 30 2010
Finish Date
Mar 20 2013
Protocol ID
368
Protocol Type
Reference Set
Fields of Research
  • Proteomics
Collaborative Group
Prostate and Urologic Cancers Research Group
Cancer Types
  • Malignant neoplasm of prostate
Phased Status
2

Associated Forms