PASS Reference Set Application: Lin UW (2010) TMPRSS2-ERG-PCA-PASS
- Abbreviated Name
- PASS Ref Set App: Lin (2010) TMPRSS2-ERG
- Lead Investigator
- Lin UW, Daniel W. — University of Washington
- Coordinating Investigator
- No coordinating investigator
- Involved Investigators
Abstract
No abstract availalbe.
Aims
1. Assess the frequency of TMPRSS2:ERG gene-fusion in whole urines of an active surveillance population. 2. Evaluate urinary TMPRSS2:ERG and PCA3 levels and assess if there is a correlation with progression. 3. Evaluate longitudinal changes in urinary TMPRSS2:ERG and PCA3 levels and assess if there is a correlation with progression.
Analytic Method
Gen-Probes TMA assay
Outcome
Active surveillance is used to manage low-risk prostate cancer. Both PCA3 and TMPRSS2:ERG are promising biomarkers that may be associated with aggressive disease. This study examines the correlation of these biomarkers with higher cancer volume and grade determined at the time of biopsy in an active surveillance cohort.
Publications
Biomarkers
Data Collections
- No data collections available at this time for this protocol.
- Start Date
- Jun 30 2010
- Finish Date
- Mar 20 2013
- Protocol ID
- 368
- Protocol Type
- Reference Set
- Fields of Research
-
- Proteomics
- Collaborative Group
- Prostate and Urologic Cancers Research Group
- Cancer Types
-
- Malignant neoplasm of prostate
- Phased Status
- 2