Abbreviated Name

Breast Ref Set App: Abbott (2013)

Lead Investigator

Abbott, Karen — Florida International University

Coordinating Investigator

Zheng, Yingye — Fred Hutchinson Cancer Center

Involved Investigators

• Abbott, Karen — Florida International University
• Zheng, Yingye — Fred Hutchinson Cancer Center

Abstract

No abstract availalbe.

Aims

Validating B 1,6 as a biomarker for the early detection of breast cancer. Then continuing to validate L-PHA with the use of Breast Reference Set 2 samples.

Analytic Method

The analysis for LPHA-periostin will be similar. In each case, data will be fit to the fixed-effects linear model yij = u + ai + Bj+ eij, wehre yij is the level, u is the grand mean, ai represent the pairing effect (age-matching), bj the tumor/normal effect,and eij random variation. Transformations of the response levels will be analyzed with the method of Box and Cox (1964); based on the preliminary data we anticipate the log transformation will be adequate. Basic plots of the transformed data will be analyzed for skewness and outliers.

Comments

No comments available.

Outcome

The marker LPHA reactive periostin protein was measured on 30 invasive breast cancer case and 30 benign breast disease control plasma samples. No association was found between the marker and case-control status.

Secure Outcome

No secure outcome available.

Publications

• No publications available at this time for this protocol.

Biomarkers

• LPHA
• POSTN

Data Collections

• No data collections available at this time for this protocol.

Start Date

Aug 28 2013

Estimated Finish Date

Dec 28 2013

Finish Date

Aug 20 2015

Protocol ID

378

Protocol Type

Reference Set

Fields of Research

• Glycomics

Collaborative Group

Breast and Gynecologic Cancers Research Group

Cancer Types

• Malignant neoplasm of breast