Abbreviated Name

BRSCW Ref Set App: Abbott (2014)

Lead Investigator

Abbott, Karen — Florida International University

Coordinating Investigator

Zheng, Yingye — Fred Hutchinson Cancer Center

Involved Investigators

• Abbott, Karen — Florida International University
• Zheng, Yingye — Fred Hutchinson Cancer Center

Abstract

See objectives

Aims

We would like to used pooled reference samples to develop a sensitive magnetic bead-based assay to detect these glycoproteins with bisecting and core fucosylation changes. We have purified fusion-tagged glycoproteins with the specific glycan structures that we will spike into the control samples to determine the range and variation of detection prior to the phase II sample analysis. We will also measure the variance between the malignant ovarian cancer pooled samples and control benign pooled samples to determine if the assay can measure statistically significant differences.

Analytic Method

Data will be analyzed by the DMCC

Outcome

See objectives

Publications

• No publications available at this time for this protocol.

Biomarkers

• No biomarkers available at this time for this protocol.

Data Collections

• No data collections available at this time for this protocol.

 Team Project

Finish Date

Jul 19 2015

Protocol ID

395

Protocol Type

Reference Set

Fields of Research

• Glycomics

Collaborative Group

Breast and Gynecologic Cancers Research Group

Cancer Types

• Malignant neoplasm of breast

Phased Status

1