Abbreviated Name

Liver Rapid Ref Set App: Villanueva (2019)

Lead Investigator

Villanueva, Augusto — Icahn School of Medicine at Mt. Sinai

Coordinating Investigator

Zheng, Yingye — Fred Hutchinson Cancer Center

Involved Investigators

• Srivastava, Sudhir — National Cancer Institute
• Villanueva, Augusto — Icahn School of Medicine at Mt. Sinai
• Zheng, Yingye — Fred Hutchinson Cancer Center

Abstract

No abstract availalbe.

Aims

No aims available.

Analytic Method

No analytic method available.

Outcome

The fitted probabilities from the model achieved an AUC of 0.52 with higher probabilities indicating a higher risk for HCC. Using the threshold of 0.9469234 (positive prediction if fitted probabilities were greater than 0.9469234), we obtained a point sensitivity and specificity of 0.32 and 0.62 respectively. The fitted probabilities did not perform better than the AFP reference biomarker. For AFP: AUC = 0.81, Sensitivity at 90% specificity = 0.58. For fitted probabilities: AUC = 0.52, Sensitivity at 90% specificity = 0.22.

Publications

• No publications available at this time for this protocol.

Biomarkers

• Cancer-specific overexpression of small RNA precursors in exosomes

Data Collections

• No data collections available at this time for this protocol.

 Team Project

Start Date

Aug 8 2019

Estimated Finish Date

Dec 8 2019

Finish Date

May 24 2021

Protocol ID

462

Protocol Type

Reference Set

Fields of Research

• UNKNOWN

Collaborative Group

G.I. and Other Associated Cancers Research Group

Cancer Types

• Liver cell carcinoma

Phased Status

1