Abbreviated Name

Liver Rapid Ref Set App: Villanueva (2019)

Lead Investigator

Villanueva, Augusto — Icahn School of Medicine at Mt. Sinai

Coordinating Investigator

Zheng, Yingye — Fred Hutchinson Cancer Center

Involved Investigators

• Srivastava, Sudhir — National Cancer Institute
• Villanueva, Augusto — Icahn School of Medicine at Mt. Sinai
• Zheng, Yingye — Fred Hutchinson Cancer Center

Abstract

Analyses are based on model (mod_fit_rms_EDRN_pen_with_age_and_sex) and dataset (EDRN_prediction_results_without_age_and_sex)

Aims

Analyses are based on model (mod_fit_rms_EDRN_pen_with_age_and_sex) and dataset (EDRN_prediction_results_without_age_and_sex)

Analytic Method

Analyzed by DMCC

Comments

No comments available.

Outcome

The fitted probabilities from the model achieved an AUC of 0.52 with higher probabilities indicating a higher risk for HCC. Using the threshold of 0.9469234 (positive prediction if fitted probabilities were greater than 0.9469234), we obtained a point sensitivity and specificity of 0.32 and 0.62 respectively. The fitted probabilities did not perform better than the AFP reference biomarker. For AFP: AUC = 0.81, Sensitivity at 90% specificity = 0.58. For fitted probabilities: AUC = 0.52, Sensitivity at 90% specificity = 0.22.

Secure Outcome

No secure outcome available.

Publications

• No publications available at this time for this protocol.

Biomarkers

• Cancer-specific overexpression of small RNA precursors in exosomes

Data Collections

• No data collections available at this time for this protocol.

 Team Project

Start Date

Aug 8 2019

Estimated Finish Date

Dec 8 2019

Finish Date

May 24 2021

Protocol ID

462

Protocol Type

Reference Set

Fields of Research

• Proteomics

Collaborative Group

G.I. and Other Associated Cancers Research Group

Cancer Types

• Liver cell carcinoma

Phased Status

1