Quantitative Methylation Specific Polymerase Chain Reaction Gene Patterns in Urine Sediment Distringuish Prostate Cancer Patients From Control Subjects
- Abbreviated Name
- Quantitative Methylation Specific Polymerase Chain Reaction Gene Patterns in Urine Sediment Distringuish Prost
- Lead Investigator
- Sidransky, David — Johns Hopkins University
- Coordinating Investigator
- Sidransky, David — Johns Hopkins University
- Involved Investigators
Abstract
see publication
Aims
see publication
Analytic Method
see publication
Comments
No comments available.
Outcome
Promoter hypermethylation of at least one of the genes studied was was detected in urine samples from all 52 prostate cancer patients. Urine samples from the 91 controls without evidence of genitourinary cancer revealed no methylation of the p16, ARF, MGMT, and GSTP1 gene promoters, whereas methylation of RARBeta2, TIMP3, CDH1, Rassf1A and APC was detected at low levels.
Secure Outcome
No secure outcome available.
Publications
Biomarkers
- No biomarkers available at this time for this protocol.
Data Collections
- No data collections available at this time for this protocol.
Team Project
- Start Date
- Jan 1 2005
- Estimated Finish Date
- Sep 20 2005
- Finish Date
- Sep 20 2005
- Protocol ID
- 481
- Protocol Type
- Single
- Fields of Research
-
- UNKNOWN
- Collaborative Group
- Prostate and Urologic Cancers Research Group
- Cancer Types
-
- Malignant neoplasm of prostate
- Phased Status
- 1