7:00 AM–8:00 AM

Check-in and Breakfast (Complimentary for hotel guests and $50 for breakfast and lunch for local attendees)

8:00 AM–10:25 AM

Session 3: Early Detection/Screening

Session Chairs:

• Matthew Schabath, PhD, H. Lee Moffitt Cancer Center and Research Institute, Inc.
• Eric Grogan, MD, Vanderbilt University Medical Center
• Guillermo Marquez, National Cancer Institute
• Nick Hodges, PhD, National Cancer Institute

8:00–8:05 AM

Opening Remarks

8:05–8:25 AM

8:25–8:30 AM Q&A

Early Detection: A Patient's Story

Shira Boehler (Patient Advocate), Cancer Doesn’t Care

8:30–8:50 AM

8:50–8:55 AM Q&A

Single-Cell Spatial Transcriptomic Signatures of Early Stage Ovarian Pre-Cancer

Alexander Xu, PhD, University of Maryland

8:55 AM–9:05 AM

Break

9:05–9:25 AM

9:25–9:30 AM Q&A

Disaggregating contributions to lung-cancer mortality reductions from stage-shift and “intrastage-shift” in the National Lung Screening Trial

Hormuzd Katki, PhD, American Cancer Society

9:30–950 AM

9:50–9:55 AM Q&A

Discovery and validation of novel blood-based biomarkers to improve the screening and early detection of breast cancer

Christopher Li, MD, PhD, Fred Hutchinson Cancer Center

9:55–10:25 AM

Panel Discussion – All Session Speakers and Chairs

10:25 AM–10:40 AM

Break

10:40 AM–11:15 AM

Poster Lightning Talks

Session Chairs:

• Jillian Phallen, PhD, Johns Hopkins University
• Pei Wang, PhD, Icahn School of Medicine at Mount Sinai
• Matthew Young, PhD, National Cancer Institute

10:40–10:45 AM

Opening Remarks

10:45–10:50 AM

Talk 1: Biomarker Panels for the Early Detection of Pancreatic Adenocarcinoma Should be Tailored Based on the Indication for Surveillance

Lynette Smith, PhD, University of Nebraska Medical Center

10:50–10:55 AM

Talk 2: Integrated Genotypic-Phenotypic Biomarker Fusion with AI-Driven Decision Support for Point-of-Care Detection of HPV-Driven Head and Neck Cancer

Roya Khosravi-Far, PhD, PLD, InnoTech Precision Medicine, Inc.

10:55–11:00 AM

Talk 3: Fred Hutchinson CVC: AI-Driven Near-term Breast Cancer Risk Prediction Using 3D MRI

Lucas Liu, PhD, Fred Hutchinson Cancer Center

11:00–11:05 AM

Talk 4: Utility of microRNAs from extracellular vesicle as blood-based biomarkers for lung cancer diagnosis

Jun Chieh Tsay, MD, New York University

11:05–11:10 AM

Talk 5: Prospective Validation of Automated Imaging Scoring System, Habitat Risk Score (HRS), for Prostate Cancer Detection

Radka Stoyanova, PhD, University of Miami

11:10–11:15 AM

Talk 6: Building a staged cell-free DNA methylation and fragmentomics workflow for cancer screening and tumor tissue-of-origin prediction using EM-seq datasets

Katie Farney, BS, National Human Genome Research Institute, National Institutes of Health; Johns Hopkins University

11:15 AM–11:45 AM

11:45-11:50 AM Q&A

KEYNOTE: Spatial and liquid ecotyping of the tumor microenvironment

Aaron Newman, PhD, Stanford University

11:50 AM–1:45 PM

Lunch (Complimentary for hotel guests and $50 for breakfast and lunch for local attendees)

11:50 AM–1:45 PM

Poster Session

1:45 PM–4:25 PM

Session 4: Surveillance

Session Chairs:

• Abhijit Patel, MD, Yale University
• Jun-Chieh Tsay, MD, New York University
• Guillermo Marquez, PhD, National Cancer Institute
• Matthew Young, PhD, National Cancer Institute

1:45–1:50 PM

Opening Remarks

1:50–2:10 PM

2:10–2:15 PM Q&A

Multidimensional cell-free DNA analysis for cancer detection, risk stratification and MRD

Aadel Chaudhuri, MD, PhD, Mayo Clinic

2:15–2:35 PM

2:35–2:40 PM Q&A

Novel Strategies for the Early Detection of Hepatocellular Carcinoma

Jorge Marrero, MD, University of Pennsylvania

2:40 PM - 2:50 PM

Break

2:50–3:10 PM

3:10–3:15 PM Q&A

Advances in Blood-Based Cancer Screening: CRC Screening to Multicancer Detection

Minetta Liu, MD, Natera

3:15–3:35 PM

3:35–3:40 PM Q&A

Tracking tumor mutations through extracellular vesicle mRNA: from cancer detection to treatment monitoring

Hakho Lee, PhD, Mass General Brigham

3:40–3:55 PM

3:55-4:00 PM Q&A

Progress in lung cancer research in the eyes of an oncologist

Robert A. Winn, MD, Fox Chase Cancer Center

4:00–4:20 PM

Panel Discussion – All Session Speakers and Chairs

4:20 PM–4:40 PM

Break

4:40 PM–5:30 PM

Early Career Investigators

Session Chairs:

• Jeff Tosoian, Vanderbilt Medical Center
• Abhijit Patel, MD, Yale University
• Indu Kohaar, PhD, National Cancer Institute
• Wendy Wang, PhD, National Cancer Institute

4:40–4:45 PM

Opening Remarks

4:45–4:55 PM

4:55–5:00 PM Q&A

Plasma Proteomic Profiling of Aggressive Prostate Cancer

Mamie Lih, PhD, Johns Hopkins University

5:00–5:10 PM

5:10–5:15 PM Q&A

Statistical modeling of genome-wide cfDNA methylation for early cancer detection

Daniel Schwartz, PhD, Massachusetts General Hospital

5:15–5:25 PM

5:25–5:30 PM Q&A

From Postdoc to Site PI: Building research capacity through collaboration with AHEAD and the EDRN

Brittney Dickey, PhD, MPH, University of Nebraska Medical Center

5:30 PM

Adjourn Day 2 of EDRN Scientific Workshop