8 Gene Panel for Barretts Esophagus
- Aliases
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- 8 Gene Panel for Barretts Esophagus
- 8-gene Panel for Barrett's Esophagus
- Meltzer 8-marker panel for Esophageal Adenocarcinoma
- Description
- Eight methylation biomarkers - p16, RUNX3, HPP1 (HGNC name TMEFF2), NELL1, TAC1, SST, AKAP12 and CDH13 - were tested in a restrospective multicenter double-blinded validation study for their accuracy in predicting neoplastic progression in Barretts Esophagus. Hypermethylation of p16, RUNX3 and HPP1 has been show to occur in early Barretts Esophagus-related neoplastic progression and predicts progression risk. Several of the panel (NELL1, TAC1, SST, AKAP12 and CDH13) were also shown to be methylated early and often in Barretts Esophagus-related neoplastic progression.
Attributes
- QA State
- Accepted
- Type
- Genomic
- HGNC Name
- Certifications
- QA State for Esophagus
- Under Review
Non-Public Biomarker
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- A multicenter, double-blinded validation study of methylation biomarkers for progression prediction in Barrett's esophagus.
- CpG island hypermethylation in progression of esophageal and gastric cancer.
- Inactivation of p16, RUNX3, and HPP1 occurs early in Barrett's-associated neoplastic progression and predicts progression risk.
- Promoter hypermethylation of CDH13 is a common, early event in human esophageal adenocarcinogenesis and correlates with clinical risk factors.
- Three-tiered risk stratification model to predict progression in Barrett's esophagus using epigenetic and clinical features.
- No resources were specified for this biomarker.