AFP-L3
- Aliases
-
- AFP-L3
- Lectin-bound alpha-fetoprotein
- lectin-bound AFP
- Description
- AFP-L3, also known as lectin-bound AFP, is an isoform of AFP, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. The L3 isoform is specific to malignant tumors and its detected presence may serve to identify patients who could benefit from monitoring for the development of HCC in high risk populations (i.e. chronic hepatitis, liver cirrhosis).
Attributes
- QA State
- Curated
- Type
- Protein
- HGNC Name
- AFP-L3
- Certifications
- QA State for Liver
- Curated
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
- AFP-L3: a new generation of tumor marker for hepatocellular carcinoma.
- Alpha-fetoprotein, des-gamma carboxyprothrombin, and lectin-bound alpha-fetoprotein in early hepatocellular carcinoma.
- Des-gamma-carboxyprothrombin, alpha-fetoprotein and AFP-L3 in patients with chronic hepatitis, cirrhosis and hepatocellular carcinoma.
- Risk factors for hepatocellular carcinoma may impair the performance of biomarkers: a comparison of AFP, DCP, and AFP-L3.
- Serum tumor markers for detection of hepatocellular carcinoma.
- FDA web page describing approval of AFP-L3
- GeneCards entry for human AFP, of which AFP-L3 is an isoform
- HGNC entry 317 for AFP, human alpha-fetoprotein, of which AFP-L3 is an isoform
- Protein RefSeq sequence for alpha-fetoprotein precursor [Homo sapiens]
- UniProtKB/Swiss-Prot entry P02771 human Alpha-fetoprotein
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.