DCC
- Aliases
-
- CRC18
- CRCR1
- Colorectal cancer suppressor
- DCC
- IGDCC1
- Immunoglobulin superfamily DCC subclass member 1
- Tumor suppressor protein DCC
- colorectal cancer suppressor
- colorectal tumor suppressor
- deleted in colorectal cancer protein
- deleted in colorectal carcinoma
- immunoglobulin superfamily DCC subclass member 1
- immunoglobulin superfamily, DCC subclass, member 1
- netrin receptor DCC
- tumor suppressor protein DCC
- Description
- DCC is a receptor for netrin 1, which is required for axon guidance. DCC is a transmembrane protein and a member of the immunoglobulin superfamily of cell adhesion molecules. It mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. The cytoplasmic tail of DCC interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
Attributes
- QA State
- Curated
- Type
- Protein
- HGNC Name
- DCC
- Certifications
-
- None
- QA State for Head and Neck
- Curated
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
- Certifications
-
- None
- QA State for Lung
- Under Review
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
- An epigenetic marker panel for detection of lung cancer using cell-free serum DNA.
- NID2 and HOXA9 promoter hypermethylation as biomarkers for prevention and early detection in oral cavity squamous cell carcinoma tissues and saliva.
- The state of molecular biomarkers for the early detection of lung cancer.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.