MCAM
- Aliases
-
- CD146
- CD146 antigen
- Cell surface glycoprotein P1H12
- Gicerin
- MCAM
- MUC18
- Melanoma cell adhesion molecule
- Melanoma-associated antigen A32
- Melanoma-associated antigen MUC18
- S-endo 1 endothelial-associated antigen
- cell surface glycoprotein MUC18
- cell surface glycoprotein P1H12
- melanoma adhesion molecule
- melanoma cell adhesion molecule
- melanoma-associated antigen A32
- melanoma-associated antigen MUC18
- Description
- From UniProtKB/Swiss-Prot: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.
Attributes
- QA State
- Curated
- Type
- Glycomic
- HGNC Name
- MCAM
- Certifications
-
- None
- QA State for Head and Neck
- Curated
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
- Certifications
-
- None
- QA State for Liver
- Under Review
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
- Certifications
-
- None
- QA State for Prostate
- Under Review
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.
- An accurate prostate cancer prognosticator using a seven-gene signature plus Gleason score and taking cell type heterogeneity into account.
- Diagnosis of prostate cancer using differentially expressed genes in stroma.
- Expression changes in the stroma of prostate cancer predict subsequent relapse.
- NID2 and HOXA9 promoter hypermethylation as biomarkers for prevention and early detection in oral cavity squamous cell carcinoma tissues and saliva.
Non-Public Biomarker
Organ-specific information for this biomarker is currently being annotated or is "under review". Logging in may give you privileges to view additional information. Contact the Informatics Center if you believe you should have access.